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Listar por autor "Pérez Mejías, Gonzalo"
Mostrando ítems 1-12 de 12
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Artículo
Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle
Morse, Paul T.; Pérez Mejías, Gonzalo; Wan, Junmei; Turner, Alice A.; Márquez Escudero, Inmaculada; Kalpage, Hasini A.; Vaishnav, Asmita; Zurek, Matthew P.; Huettemann, Philipp P.; Kim, Katherine; Arroum, Tasnim; Rosa Acosta, Miguel Ángel de la; Chowdhury, Dipanwita Dutta; Díaz Moreno, Irene; Hüttemann, Maik (Springer Nature, 2023)Skeletal muscle is more resilient to ischemia-reperfusion injury than other organs. Tissue specific post-translational ...
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Cytochrome c: Surfing Off of the Mitochondrial Membrane on the Tops of Complexes III and IV
Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2019)The proper arrangement of protein components within the respiratory electron transport chain is nowadays a matter of intense ...
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Exploring protein phosphorylation by combining computational approaches and biochemical methods
Pérez Mejías, Gonzalo; Velázquez Cruz, Alejandro; Guerra Castellano, Alejandra; Baños Jaime, Blanca; Díaz Quintana, Antonio Jesús; González Arzola, Katiuska; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Elsevier, 2020)Post-translational modifications of proteins expand their functional diversity, regulating the response of cells to a ...
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Mitochondrial cytochrome c shot towards histone chaperone condensates in the nucleus
González Arzola, Katiuska; Guerra Castellano, Alejandra; Rivero Rodríguez, Francisco; Casado Combreras, Miguel Ángel; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Rosa Acosta, Miguel Ángel de la (Wiley-Blackwell, 2021)Despite mitochondria being key for the control of cell homeostasis and fate, their role in DNA damage response is usually ...
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Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
González Rellán, María J.; Fernández, Uxía; Parracho, Tamara; Novoa, Eva; Fondevila, Marcos F.; Da Silva Lima, Natalia; Rodríguez, Amaia; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Díaz Moreno, Irene; Nogueiras, Rubén (Elsevier, 2023)Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed ...
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Tesis Doctoral
Novel insights into the mechanism of electron transfer in mitochondrial cytochrome c and its regulation by post-translational modifications
Pérez Mejías, Gonzalo (2023-06-30)Las células que componen nuestro cuerpo obtienen la mayor parte de la energía que necesitan para vivir, de los alimentos ...
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Oxidative stress is tightly regulated by cytochrome c phosphorylation and respirasome factors in mitochondria
Guerra Castellano, Alejandra; Díaz Quintana, Antonio Jesús; Pérez Mejías, Gonzalo; Elena-Real, Carlos A.; González Arzola, Katiuska; García Mauriño, Sofía M.; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (National Academy of Sciences, 2018)Respiratory cytochrome c has been found to be phosphorylated at tyrosine 97 in the postischemic brain upon neuroprotective ...
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Phosphorylation disrupts long-distance electron transport in cytochrome c
Gomila, Alexandre M.J.; Pérez Mejías, Gonzalo; Nin-Hill, Alba; Guerra Castellano, Alejandra; Casas Ferrer, Laura; Ortiz Tescari, Sthefany; Díaz Quintana, Antonio Jesús; Samitier, Josep; Rovira, Carme; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene; Gorostiza, Pau; Giannotti, Marina I.; Lagunas, Anna (Springer Nature, 2022)t has been recently shown that electron transfer between mitochondrial cytochrome c and the cytochrome c1 subunit of the ...
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Post-Translational Modifications of Cytochrome c in Cell Life and Disease
Guerra Castellano, Alejandra; Márquez Escudero, Inmaculada; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (MDPI, 2020)Mitochondria are the powerhouses of the cell, whilst their malfunction is related to several human pathologies, including ...
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Proposed mechanism for regulation of H2O2-induced programmed cell death in plants by binding of cytochrome c to 14-3-3 proteins
Elena-Real, Carlos A.; González Arzola, Katiuska; Pérez Mejías, Gonzalo; Díaz Quintana, Antonio Jesús; Velázquez Campoy, Adrián; Desvoyes, Bénédicte; Gutiérrez, Crisanto; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Wiley-Blackwell, 2021-04)Programmed cell death (PCD) is crucial for development and homeostasis of all multicellular organisms. In human cells, the ...
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Structural and functional insights into lysine acetylation of cytochrome c using mimetic point mutants
Márquez Escudero, Inmaculada; Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Olloqui Sariego, José Luis; Andreu Fondacabe, Rafael Jesús; Calvente Pacheco, Juan José; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Wiley-Blackwell, 2021)Post-translational modifications frequently modulate protein functions. Lysine acetylation in particular plays a key role ...
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Wheel and Deal in the Mitochondrial Inner Membranes: The Tale of Cytochrome c and Cardiolipin
Díaz Quintana, Antonio Jesús; Pérez Mejías, Gonzalo; Guerra Castellano, Alejandra; Rosa Acosta, Miguel Ángel de la; Díaz Moreno, Irene (Hindawi, 2020)Cardiolipin oxidation and degradation by different factors under severe cell stress serve as a trigger for genetically ...